Selective Serotonin Reuptake Inhibitor – SSRI – are an inclusion to the anti-depressant drugs system. This group of medicaments aid in preventing the neurotransmitter serotonin from being re-absorbed by the particular nerve cell that causes the release of it. This then allows the serotonin to remain active within the body’s electro-chemical computational nutrients via any resultant drugs issued by doctors. SSRI’s have been proved to relieve the symptoms of the trauma of depression - in some people. Read on I will explain. The following are SSRI drugs and can also be used for the traumac of lows involved in trauma of Bi-polar as well.
• Celexa (citalopram)
• Lexapro (escitalopram)
• Luvox (fluvoxamine)
• Paxil (paroxetine)
• Prozac (fluoxetine)
• Zoloft (sertraline)
Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitors (SSRI’s) are a class of compounds typically used as anti-depressants in the treatment of major traumatic depressive disorders and also the trauma of anxiety disorders as well.
SSRI’s are said to cause an increase in the extracellular level of the neurotransmitter serotonin by reducing the re-absorption into the presynaptic cell. This then increases the level of serotonin in the synaptic cleft available to bond into the postsynaptic receptor. They have varying degrees of compatibility for the other monoamine transporters (Protein structures), with pure SSRI’s having only weak bonding for the norepinephrine and dopamine transporters.
Electro-chemical synapses (Post and Pre synaptic cells) are specialized electro-chemical junctions through which neurons (brain) signal to each other and also to non-neuronal cells such as those of the muscles or glands. Chemical synapses allow neurons to form electro-chemical circuits within the central nervous system in the trauma of the brain/body barrier. They are essential for the biological computations that form Psychosocial perception (sight and hearing) and Psychosocial peripheral thought (feelings). They allow the nervous system to connect to and control other systems of the body mentalist attitude.
The trauma of Discontinuation syndrome.
Serotonin reuptake inhibitors should not be abruptly discontinued after extended therapy, and whenever possible, should be tapered over several weeks to minimize discontinuation-related symptoms which may include nausea, headache, dizziness, chills, body aches, paresthesias, insomnia, and electric shock-like sensations.
Paroxetine might possibly produce a discontinuation-relational set of symptoms of side-effects compared to other SSRI’s, although largely similar side-effects have been accounted for all SSRI’s. The trauma of Discontinuation side-effects are less for the trauma of fluoxetine, perhaps because of its extended half-life and its naturally thinning effect that is associated with its slow clearance from the body. One method for minimization of the SSRI traumatic discontinuation symptoms is to switch the patient to the trauma of fluoxetine and then allow for natural thinning in the body via the fluoxetine.
A Cholinergic is a term that refers to any compound that has the ability to increase levels of acetylcholine or choline in the brain. This is usually reserved for compounds that give the body choline (Choline, Alpha-GPC) or inhibit the breakdown of acetylcholine, causing an indirect increase (Huperzine-A)
Popular forms of substrate cholinergics:
Popular forms of Non-substrate cholinergics:
Anyway SSRI’s are widely prescribed anti-depressants throughout many countries. The efficiency of SSRI’s in mild or moderate cases of the trauma of depression have been contested.
Logically Protein drinks become the necessity for aiding SSRI’s in their work in the body/brain barrier. Food such as whey protein contains nutrients for the Acetylcholine production in the body.
Choline is a water soluble B vitamin which can be produced in the human body, but natural quantities can often be in: insufficient amounts in some traumatized mental health clients. Natural sources of choline include:
and organ meats.
Bitarate is added to the choline to enhance the absorption rate within the human body in the supplemental version.
The World Health Organisation (WHO) states “Health is a state of complete physical, mental and social well-being and not merely the absence of disease or trauma of infirmity”. This website is designed to give maximum mental health wellbeing via: social life and personal care improvements via Self-Behavioural Analysis (SBA) and physical dietary information. What I would say to W.H.O is: that modern life needs high level nutritional mineral supplements and liquids. Controversy is in the amount that can be absorbed but what I say is the amount of water intake defines the amount absorbed into the system. I can drink up to 16 pints of liquid (not alcohol) a day (I would not recommend that amount straight away to all of you) when I am taking my full range of mineral supplements daily. This I say is why my body and mind can ingest most of the RDA dosage in the mineral supplements. It’s keeping the liquid in that’s important as well.
Anti-depressants are recommended as an alternative or additional inclusion to self-help programs in the treatment of the trauma of bulimia nervosa. SSRI’s - particularly fluoxetine are preferred over other types of anti-depressant medicaments due to its acceptability, tolerance levels, and a superiority in reducing symptoms in short-term trials of the drug. Reports from extended usage into its efficiency remains poorly researched.
Similar considerations apply to the trauma of binge eating disorder as well. SSRI’s provide short-term reductions in the trauma of binge eating behaviors, but that no significant problems with significant weight loss had occurred.
Clinical trials have produced mostly negative results in the usage of SSRI’s in the treatment of the trauma of anorexia nervosa. Treatment guidelines from the NICE recommend against the use of SSRI’s in this disorder. Those from the American Psychiatric Association note that ‘SSRI’s confer no advantage regarding weight gain, but that they may be used for the treatment of co-existing trauma of depressive, traumatic anxiety, or traumatic obsessive-compulsive disorders’.
I as a user of Olanzapine I would definitely give recommendation towards using this for the trauma of anorexia nervosa. At times this medication causes great hunger until you cannot stand it any further and have to eat. Several psychiatrists will testify I’m sure that this is a natural side-effect of Olanzapine.
The trauma of Depression.
Anti-depressants are recommended by the National Institute for Clinical Excellence (NICE) as a first-line treatment of the trauma of severe depression and for the treatment of mild-to-moderate trauma of depression that persists after conservative measures such as cognitive therapy. They recommend against their routine use in those who have chronic trauma of mental health problems and mild trauma of depression.
There has been controversy regarding the efficiency of anti-depressants in treating trauma of depression depending on its severity and duration.
• Two meta-analyses published in 2008 (Kirsch) and 2010 (Fournier) found that in mild and moderate trauma of depression, the effect of SSRIs is small or none compared to a placebo, while in very severe traumatic depression the effect of SSRI’s is between "relatively small" and "substantial". The 2008 meta-analysis combined 35 clinical trials submitted to the U.S. Food and Drug Administration (FDA) before the licensing of four newer anti-depressants. These include the SSRI’s paroxetine and fluoxetine and the non-SSRI anti-depressant nefazodone, and the serotonin and norepinephrine reuptake inhibitor (SNRI) venlafaxine. The authors attributed the relationship between severity and efficiency to a reduction of the placebo effect in severely traumatized depressed patients, rather than an increase in the effect of the medication. Some researchers have questioned the statistical basis of this study suggesting that it underestimates the effect size of anti-depressants.
• A 2010 comprehensive review conducted by NICE concluded that anti-depressants have no advantage over placebo in the treatment of short-term mild trauma of depression, but that the available evidence supported the use of anti-depressants in the treatment of dysthymia and other forms of chronic mild trauma of depression.
• A 2012 meta-analysis of fluoxetine and venlafaxine concluded that statistically and clinically significant treatment effects were observed for each drug relative towards a placebo irrespective of baseline depression severity.
• In 2014 the U.S.A FDA published a systematic review of all anti-depressant maintenance trials submitted to the agency between 1985 and 2012. The authors concluded that maintenance treatment reduced the risk of relapse by 52% compared to placebo, and that this effect was primarily due to recurrent trauma of depression in the placebo group rather than a drug withdrawal effect.
• A study examining publication of results from FDA-evaluated anti-depressants concluded that those with favorable results were much more likely to be published than those with negative results.
There does not appear to be a big difference in the effectiveness among the second generation anti-depressants (SSRI’s and SNRI’s).
Meta analyses of short duration randomized clinical trials have found that SSRI use is related to a higher risk of traumatic suicidal behavior in children and adolescents. It is unclear whether or not SSRI’s affect the risk of traumatic suicidal behavior for adults. In children there are concerns around the quality of evidence on the meaningfulness of benefits seen. If a medication is used, fluoxetine appears to be first line of medicament.
Generalized anxiety disorder
SSRI’s are recommended by (N.I.C.E) as a treatment of generalized trauma of anxiety disorder (GAD) for someone that has not responded to methods such as education, Self-Behavioral methods or Cognitive Behavioral Therapy, although C.B.T is in all likelihood given during usage of the medicaments. G.A.D is a common trauma disorder for which the central belief of Self is causing excessive worry about a number of different events within their life. Symptoms include the trauma of excessive anxiousness about multiple events and issues, and difficulty controlling troublesome thoughts and that persist for around 6 months.
Anti-depressants provide a modest-to-moderate reduction in the trauma of anxiety in GAD, and are superior to placebo in treating G.A.D. The efficiency of differing anti-depressants is similar.
Meta analyses of short duration randomized clinical trials have found that SSRI use is related to a higher risk of trauma of suicidal behavior in children and adolescents. It is unclear whether or not SSRI’s affect the risk of trauma of suicidal behavior for adults.